Surfactant-based Transdermal System for Fluconazole Skin Delivery
نویسندگان
چکیده
منابع مشابه
Skin electroporation for transdermal and topical delivery.
Electroporation is the transitory structural perturbation of lipid bilayer membranes due to the application of high voltage pulses. Its application to the skin has been shown to increase transdermal drug delivery by several orders of magnitude. Moreover, electroporation, used alone or in combination with other enhancement methods, expands the range of drugs (small to macromolecules, lipophilic ...
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1 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra Baddi. Distt Solan, H.P., India. 2 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra Baddi. Distt Solan, H.P., India. 3 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra B...
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Methotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin diseases, however, MTX presents a number of side effects, such as hepatotoxicity. To overcome this limitation, this study developed skin MTX delivery surfactant systems, such as a microemulsion (ME) and a liquid crystalline system (LCS), consisting of a glycol copolymer-based silicone fluid (SFGC) as oil p...
متن کاملTransdermal drug delivery systems: skin perturbation devices.
Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight < 500 Da. The number of commercially available products based on transdermal or dermal delivery has been limited by these requirements. In recent y...
متن کاملTransdermal alniditan delivery by skin electroporation.
The aim of this study was to evaluate the transdermal permeation of alniditan by electroporation and to compare with iontophoretic delivery. The influence of the electrical parameters of electroporation was investigated in vitro using a factorial design study. The transdermal flux of alniditan was enhanced by two orders of magnitude by application of high voltage electrical pulses. The electric...
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ژورنال
عنوان ژورنال: Journal of Nanomedicine & Nanotechnology
سال: 2014
ISSN: 2157-7439
DOI: 10.4172/2157-7439.1000231